How major improvements in chemotherapy have come about - mid-1970s


        HOW MAJOR IMPROVEMENTS IN CHEMOTHERAPY HAVE COME ABOUT - MID-1970S
In the mid-1970s, the same degree of improvement occurred in the treatment of testicular cancer. This time it was a new drug rather than a new technique (the use of high dose combinations) that was responsible for the breakthrough. A new drug called cis-platinum had been shown to be active against testicular cancer in Phase II studies. This drug, when combined with the two previously best drugs (vinblastine and bleomycin) produced complete remissions in most patients with cancer of the testes, many of whom were later shown to be cured altogether. Prior to that about one in three patients with extensive cancer of the testes experienced remissions which were only partial and temporary, cures were unusual. Again, special research techniques were not necessary to prove that the new treatment was much better than what had been used previously.
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Cancer
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